LLM-Guided Integer Linear Programming for Antibody Library Design
Date:
Conference Talk at 21st International Conference on Computational Intelligence Methods for Bioinformatics and Biostatistics (CIBB 2026), Sapienza University of Rome, Rome, Italy
Conference talk on combining large language models with integer linear programming to design antibody libraries under constraints. In the pipeline, the LLM is scoped to emitting structured-JSON priors, and a deterministic ILP solver uses them to select a library of antibody variants that satisfies the design constraints. Keeping the optimization in the solver makes the resulting libraries auditable and easy for a domain expert to inspect or override, building on the ProtLib-Designer framework for antibody library design.